Not since GRAIN BRAIN has Dr Perlmutter written a book that will shake the foundation of what we know about neurological health and healing.

'A science-based, actionable blueprint to shift the brain from decline to repair.' ? Dr David Sinclair, New York Times bestselling author of Lifespan

A ground-breaking new book from the bestselling author Dr David Perlmutter that will transform our understanding and treatment of degenerative brain diseases.

In recent years microglia cells housed in the brain have been identified as playing a key role in a host of neurodegenerative diseases such as Alzheimer's, Parkinson's, Long Covid, and MS amongst others. When operating optimally, these cells support healthy brain function. However, when they go rogue, they cause inflammation in the brain, contributing to cell death and devastating neurological conditions.

Current drug treatments mostly mask symptoms rather than cure and the statistics are grim: worldwide, 55 million people suffer from Alzheimer's, 10 million people have been diagnosed with Parkinson's, and serious neurological disorders are on a rapid rise.

And the good news? By following the lifestyle protocol that Dr David Perlmutter presents in the book people can become 'architects of their cognitive destiny'. The Brain Defenders program is accessible to all and will help us start to win the war against the scourge of neurodegenerative diseases.

Details

ISBN13: 9781399753333
Format: Paperback / softback
Number of Pages: 384
Edition:
Publication Date: 25 Aug 2026
Publisher: Hodder & Stoughton
Publication City, Country: United Kingdom
Dimensions (cm): 23.2(H)x15.2(L)x3(W)
Weight (gm):

Author Biography

Dr David Perlmutter is a board-certified neurologist and Fellow of the American College of Nutrition. He is a frequent lecturer at institutions including the World Bank, Columbia University, New York University, Yale, and Harvard, and is the recipient of numerous awards. Dr Perlmutter is the author of Grain Brain, Brain Maker, The Grain Brain Whole Life Plan, The Grain Brain Cookbook and Brain Wash.

Reviews

A science-based, actionable blueprint to shift the brain from decline to repair. * Dr. David Sinclair, Professor of Genetics, Harvard Medical School, and New York Times bestselling author of Lifespan *
David Perlmutter consistently has his finger on the pulse of the newest and most important brain health research. * Dr. Rudolph Tanzi, Professor of Neurology, Harvard Medical School, and New York Times bestselling author of Super Brain *
Brain Defenders offers a powerful roadmap grounded in rigorous science and practical application. * Dominic D’Agostino, PhD, Associate Professor, Department of Molecular Pharmacology and Physiology, USF Morsani College of Medicine *
Brain Defenders is a landmark work that puts the power of prevention in your hands. * Uma Naidoo, MD, nutritional psychiatrist, Harvard Medical School, and bestselling author of This Is Your Brain on Food *
This book is a must read for anyone seeking a roadmap on how to shore up your brain's resilience against diseases of aging. * William W. Li, MD, New York Times bestselling author of Eat to Beat Disease and Eat to Beat Your Diet *
This book is an essential resource for clinicians and informed patients who want to shift from crisis response mode to proactive brain stewardship. * Ben Greenfield, author of Boundless *
Brain Defenders is an essential read for anyone seeking to enhance mental clarity, longevity, and overall brain wellness. * Mark Sisson, founder of Primal Kitchen Foods and author of The Primal Blueprint *
Brain Defenders offers a clear, accessible look at how metabolism, inflammation, and immune function influence brain health. * Christopher Palmer, MD, assistant professor of psychiatry, Harvard Medical School, and author of Brain Energy *
Brain Defenders reveals the breakthrough biology driving today's brain health crisis-and why this research is our best shot for the future of brain health. * Austin Perlmutter, MD, coauthor of Brain Wash *