Against the sumptuous backdrop of Charleston, South Carolina, South of Broad gathers a unique cast of sinners and saints. Leopold Bloom King is the son of an amiable, loving father who teaches science at the local high school. His mother, an ex-nun, is the high school principal. After Leo's older brother commits suicide at the age of 13, the family struggles with the shattering effects of his death. Leo, lonely and isolated, searches for something to sustain him. Eventually, he finds his answer when he becomes part of a tightly knit group of high school seniors that includes friends Sheba and Trevor Poe, glamorous twins with an alcoholic mother and a prison-escapee father; hardscrabble mountain runaways Niles and Starla Whitehead; socialite Molly Huger and her boyfriend, Chadworth Rutledge X; and an ever-widening circle whose liaisons will ripple across two decades - from1960s counterculture through the dawn of the AIDS crisis in the 1980s. The ties among them endure for years, surviving marriages happy and troubled, unrequited loves and unspoken longings, hard-won successes and devastating breakdowns, and Charleston's dark legacy of racism and class divisions. But the final test of friendship that brings them to San Francisco is something no one is prepared for.